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Posts Tagged ‘anagen’

Minoxidil’s New Discovery

Sunday, July 10th, 2011

Minoxidil - medical hair restomationThere are two proven medical treatments for hair loss , aside from hair transplantation surgery, Minoxidil (Rogaine) and Finasteride (Propecia). The hair growth action mechanisms for Minoxidil are not completely understood, three main suggested mechanisms are:

1. Blood Vessels in the scalp which are impacted by Nitric oxide chemical agonists
2. Hyperpolarization of the cell membrane of follicles caused by potassium channel openers
3. The effect of nitric oxide conceivably due to Vasodilation

A recent study was conducted by Korea’s Kyungpook National University’s Department of Immunology which was published in The Journal of Dermatological Science. It revealed a new Mechanism of Minoxidil which activates the Beta-Catenin pathway in derma papilla cells, which is one of the two different cells which aids in the growth and development of hair. It was announced by those performing the research that this particular mechanism may possibly be the reason for the anagen prolongation effect. 

The duration of growth in the anagen phase (time of continual growth) is what develops hair length. The researchers underscored the fact maintenance of the activity of Beta-Catenin for the dermal papilla cells (DPCs) aids hair follicles to actively grow. Minoxidil (Rogain) gives growth remedy for male pattern baldness which suggests it can enhance the growth phase in the life cycle of hair.

A mouse model was used for the study using 3% minoxidil for a ten day duration. Beta-Catenin responsive TCF reporter plasmid was used to transfect DPC’s. The results revealed the anagen phase was extended significantly after the use of minoxidil. The researchers came to the conclusion minoxidil prolongs the activating Beta-Catenin anagen phase in DPC’s and has the potential to be a primary pathway for hair growth or the prevention mechanism for hair loss.

A study like this helps to enhance our comprehension of hair loss and growth. Over time this can help the field of hair restoration providing more options to confront hair loss with greater sufficiency.

Herbal Hair Loss Product

Wednesday, March 18th, 2009

In a recent article published in the European Journal of Dermatology, a group in Kang et has been working with a native plant known as Schisandra Nigra. This plant is native to the Jeju Island in South Korea and is being evaluated for its rumored effects on hair by natives. The study is being conducted on rat hair and is showing some promise.

Tests were conducted on rat vibrissa follicles by treating them with 85% ethanol extract of S. Nigra (Schisandra Nigra) where the most evident effect was the vibrissa follicle’s hair fiber length increased significantly. In addition to the effects of the EtOH (ethanol) extract, anagen (growth phase) progression of the hair shaft was induced. Even more so the S. Nigra extract also increased both the expression of proliferating cell nuclear antigen in the bulb matrix region and the proliferation of immortalized vibrissa dermal papilla cells with more activity on hair follicle cells.

To help researches determine what mechanism in the S. Nigra plant helps induce hair growth, they examined its relationship with the TGF-beta2 complex. This is a signal pathway known to regulate catagen induction. Catagen induction is the phase that comes after the hair cycle’s growth phase.

The documented results of S. Nigra application for 7 days was the lowering of TGF-beta2 expression in the bulb matrix region in comparison to that of the control follicles expected to be in the anagen-catagen transition phase. This suggests that S. Nigra potentially promotes hair growth by deregulating TGF-beta2 as well as the proliferation of dermal papilla.

Put simply, this plant’s extracts stop hair follicles from going into their resting phase. This means hair will continue to grow and the number of growing hairs at one time will be higher. Still, these findings cannot be proven to truly work on humans. We still need more conclusive studies to be made to prove the true effects of this plant on human hair growth.

We at our Orange County California hair transplant offices will keep you updated with the most recent finings on hair restoration methods and techniques. Because of the lack of sufficient or adequate evidence, we do not recommend the use of this or other herbal hair loss products for treatment of male or female patterned hair loss at this point. Will continue to monitor any additional findings or new updates in the world of hair restoration and keep our readers posted.