In the past 30 years, alternate types of therapy for enhancing wound repair have been mentioned. For this entry, I wanted to talk about the cutting-edge areas of stem cell therapy and gene therapy in wound healing. When it comes to gene therapy, it was first put into practice for treating congenital defects. Now, it is a fresh alternative for affecting wound repair. To speed up the process of wound closure, genes encoded for growth factors or cytokines revealed the greatest potential.

Most gene delivery systems have roots in viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells posses an extended self-renewal ability with the capacity to differentiate into various tissue types. Different types of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been used to separate stem cells to speed up the healing response of acute and chronic wounds.

Not too long ago, the grouping of gene and stem cell therapy has come to the forefront as a potential option to care for chronic and acute wounds.

For potential hair transplant patients, this breaking development about gene and stem cell therapy in hair restoration is fantastic news because a rapid healing from stitches in the donor area would make for a much quicker and painless procedure. There are all kinds of different types of hair loss, but, if a hair loss sufferer undergoes a hair transplant, it would be imperative that his stitches would heal quickly.

Source information was provided by the following authors: Branski LK, Gauglitz GG, Herndon DN, Jeschke MG.

Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, United States.

In the latest issue of the Journal of Internal Medicine, a new research study was published: “A Rare Complication: New Hair Growth Around Healing Wounds.” This study is related to Dr. Mohebi’s personal research at Johns Hopkins Medical Institute on gene therapy techniques and wound healing and how it affected the growth of mice hair.

The journal study was about a person who had hair growth surrounding a healing wound at Guangxi Medical University in Nanning, China.

The doctors involved in the study mention an incident in which hair growth occurred around a wound during the process of wound healing. Hair growth after wound healing is an atypical occurrence. This is the first time such an event had ever been recorded in scientific literature.

The doctors concluded that the wounds damaged the hair follicles and epidermis, but that it was possible for both to repair themselves if there was a suitable physical and chemical micro-environment. The doctors say that this new hypothesis may very well lead to new methods of managing hair loss, tissue engineering, and the regeneration of other organs.

At the laboratory of Johns Hopkins Medical Institute, and as part of my overall research, I did a major investigative study on hair growth as a byproduct of wound healing. On a few rats, after witnessing wound healing, to my delight, I found that some gene therapy techniques stimulated the hair growth.

My attention was on hair growth only and, coincidentally, our results matched other hair growth-wound healing studies, during 2005 to 2006. At the University of Pennsylvania, Dr. Cotsarelis, along with his contemporaries, first made public a study on the relationship between wound healing and hair growth through activation of the molecular pathway WNT.

Other similar studies have called attention to the fact that hair restoration through tissue engineering, hair multiplication, and gene therapy might one day happen and that we just may have a breakthrough a lot sooner than we expected all these years.

Parsa Mohebi, M.D.
Medical Director
US Hair Transplant