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2009 Update: Hair Growth and Thyrotropin-Releasing Hormone

Friday, October 30th, 2009

TRH in hair loss and hair restoration

The field of hair growth and hair restoration has introduced a new player to its lineup: TRH (Thyrotropin-Releasing Hormone). It is likely TRH may turn out to be a heavy hitter in the fast-growing hair transplant industry.

Just recently, a new finding in hair elongation and the hair growth cycle was published in the Journal of the Federation of American Societies for Experimental Biology (The FASEB Journal). The research was conducted in Germany by Dr. Gaspar at the top-ranked University of L’beck, Department of Dermatology and Department of Internal Medicine.

It’s been shown that Thyrotropin-Releasing Hormone (TRH) is one of the crucial elements involved in the hair follicle growth cycle. Thyrotropin-Releasing Hormone is very closely situated to the hypothalamic-pituitary-thyroid axis. This axis stabilizes thyroid hormone synthesis.

Scientists have decided to study whether human hair follicle functions are also modulated by thyrotropin-releasing hormone, because it’s been found in human tissue. According to their findings, the researchers say that the epithelium of human scalp hair follicles expresses not only TRH receptors (TRH-R), but also TRH itself at the protein and gene level.

They found stimulation of organ-cultured hair growth with thyrotropin-releasing hormone stimulates hair follicle elongation, prolongs the hair growth cycle phase (anagen), and antagonizes its termination by TGF-beta2. It also increases proliferation and inhibits the apoptosis of hair matrix keratinocytes.

So, we can conclude from the study that thyrotropin-releasing hormone operates as a legitimate potent hair-growth stimulator. It’s proven to be an ideal discovery tool for identifying functions of thyrotropin-releasing hormone are hair follicles.